Size-controlled insulin-secreting cell clusters
نویسندگان
چکیده
منابع مشابه
Size-controlled insulin-secreting cell clusters.
The search for an effective cure for type I diabetes from the transplantation of encapsulated pancreatic β-cell clusters has so far produced sub-optimal clinical outcomes. Previous efforts have not controlled the size of transplanted clusters, a parameter implicated in affecting long-term viability and the secretion of therapeutically sufficient insulin. Here we demonstrate a method based on co...
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Nestin, which was initially identified as a marker of neural stem cells, has been reported in regenerating pancreas as well as in early embryonic stem (ES) cell derivatives. However, little is known about its specific roles in stem cells as a functional regulator. We investigated the source of the action of nestin in ES and adult pancreatic ductal stem (PDS) cells in regard to the neogenesis of...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2012
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2012.08.010